BRC 100 - 4 Pages

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Catalogue excerpts

BRC 100 – the new dry granulator Dr. Dejan Djuric Dr. Dejan Djuric, Manager Scientific Operations Introduction Continuous dry granulation has been an established process in the pharmaceutical industry for decades. It is not only applied for moisture- and temperature-sensitive materials, but also for large volume or herbal products, respectively. In comparison with classical wet granulation techniques, a sophisticated drying system is not necessary. This avoids large investments for production equipment and space, and it requires only low manufacturing costs. Furthermore the fast roller compaction...

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Figure 2: Compaction force impact on granule particle size A smooth master roll and a grooved slave roll of 100 mm width were used for the compaction trials. Sampling was performed after the process start-up when steady state was reached. Final granules were manually sub sampled and analyzed in duplicate by mechanical sieving (Haver EML 200 digital, Haver&Boecker, Germany). Compaction force The impact of the compaction force on the final granule particle size was analyzed 1.5 mm rasp sieve and a gap width of 2.5 mm. The process began with activated PID loop control for the feeding system. Steady...

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during granulation and leads to lower amount of fines. Therefore, altering the sieve speed is another possibility to adjust the desired particle size distribution of the final granules. . Figure 4: Impact of screen size on granule particle size distribution Conclusion The case study proves the functionality of the new BRC 100 roller compactor. It was possible to precisely produce a representative placebo granule formulation with negligible material waste during the process start-up. Furthermore, it shows that a suitable sieve setup offers the possibility to achieve a desired granule size by altering...

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