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Brochure autoflex III & autoflex III TOF/TOF - Bruker Daltonics Inc


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CLINPROT solution package provides researchers with comprehensive tools for biomarker research: Profiling, tissue imaging and marker identification
Technical specifications
Cutting-edge technology
• smartbeam lasertechnology: Top performance with any chosen matrix, outperforming the YAG-laser.
• PAN: Highest mass resolution at every mass from 700 - 5,000 Da.
• HPC: High Precision Calibration for highest mass accuracy.
Analytical performance
• smartbeam laserwith adjustable repetition rate from 1-200 Hz.
• Excellent resolution > 1,000 and brilliant mass accuracy of<100 ppm in linear mode for protein samples; a prerequisite for MALDI Imaging and Biomarker Profiling workflows.
• Impressive resolution > 10,000 over extended mass range window (> 3,500 mass units) using Bruker Daltonics' unique PAN™ (panoramic) technology.
• Remarkable mass accuracy of<5 ppm for peptide mass range in reflectron mode.
• Striking sensitivity in attomole range with high signal-to-noise ratio in TOF/TOF mode.
Compass software suite
• flexControl for quick and easy instrument control.
• flexAnalysis for automatic and interactive data analysis.
Optional packages:
• BioTools™, the cutting edge software for protein analysis.
• WARP-LC™, the LC-MALDI and protein quantitation software.
• ClinProTools™, the software for biomarkervisualization and discovery.
• flexlmaging™, the software for MALDI imaging applications.
• ProteinScape™ database system for proteomics project management.
• CompassSecurityPack™,21CFRpart11 compliance.
BRUKER
Identification
A (MS/MS)
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autoflex III
smartbeam
Cutting edge
MALDI-TOF/TOF systems
Be a part of
Intelligent Teamwork
Maximizing data verification and understanding of scientific problems is accomplished by tight integration of analytical systems. Statistical data from the autoflexIII smartbeam, achieved with the CLINPROT solution package, can easily be merged with molecular images in the MALDI Molecular Imager system, thus allowing the monitoring of the tissue distributions of peptide and protein biomarkers.
Peak Profile Classification + MALDI Imaging = Class Imaging
ROi£(iä»2
A
B
Face to face wit
lly smart p
h
erformance
Internet Remote Control
Support features
• Extended self diagnostics.
• Remote on-line service capability.
• Supplementary IQ/OQ/PV procedures available.
• Custom-tailored maintenance contracts available.
r
a
BrukerService Board
I
Customer Lab
D
The autoflex smartbeam seamlessly integrates
into
Bruker Daltonics' system solutions:
• MALDI Molecular Imager™ - Mass Spectrometry-Based Imaging
• CLINPROT™ - Mass Spectrometry-Based BiomarkerAnalysis
• PROTEINEER-LC™ - LC-based Proteomics Suite
• PROTEINEER™ - 2D Gel-based Proteomics Suite
For research use only. Not for diagnostic procedures.
D
E
Class Imaging enhances Mass Imaging - the principle: Peak profiles (B) of defined regions of interest (ROI, A) in a tissue slice are used to calculate a classification model (C). The resulting classes (D) are then used to stain the tissue slice class-specifically (E):
Detect the spatial distribution of statistically relevant markers!
Example: Sagittal section of the cerebellum of the rat brain. (A) HA stain; (B, C) ClinProTools analysis; (D, E) MALDI Molecular Imager analysis
www.bdal.de
www.bdal.com
BRUKEi
Bruker Daltonik GmbH
Bremen ■ Germany Phone +49(421)22 05-0 Fax +49(421)22 05-104 E-Mail sales@bdal.de
Bruker Daltonics Inc.
Billerica, MA ■ USA Phone +1 (978)663-3660 Fax +1(978)667-5993 E-Mail ms-sales@bdal.com
BRUKER
DALTONICS
DALT0NÎC5
Enabling Life Science Tools Based on Mass Spectrometry™
See our website for worldwide sales and service contacts.

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