Taste Analysis Services for the Pharmaceutical Industry - Alpha MOS - #4

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They put their trust in us We have contributed to the development of a wide array of dosage forms: > Traditional: liquids, sublingual / chewable tablets > Novel: ODT, oral films, soft chews and so on Alpha M.O.S.America 7502 Connelley Drive, suite 110 Hanover, MD. 21076-1705 Ph: 410.553.97 36 Fax: 410.553.98 71 E-mail: amusa@alpha-mos.com Alpha M.O.S.Asia Suite 1002A, Shanghai Singular Mansion 322 XianXia Road Shanghai, P.R. CHINA, 200336 Ph: + 86 (0) 21 62 08 16 55 Fax: + 86 (0) 21 62 95 22 59 E-mail: asia@alpha-mos.com Alpha M.O.S Headquarters 20,Av Didier Daurat 31400 Toulouse - France Ph: + 33 5 62 47 53 80 Fax: + 33 5 61 54 56 15 E-mail: info@alpha-mos.com Visit our website: www.alpha-mos.com  A taste masking DOE study: Effect of Carbopol, pH and Amberlite  Bitterness score of quinine sulphate pellets  Partial least squares regression of human taste panel data vs. electronic tongue data S Formulations of Choice for the Paediatric Population. EMEAPaediatricWorking Party (2005). S Stability,doseuniformityandpalatabilityofthreecounterterrorismdrugs-humansubjectandelectronic tongue studies. Pharm. Res. 22(10):1747-1756 (2005). N Sadrieh and LBuhse S Utilizationofamodifiedspecial-cubicdesignandanelectronictongueforbitternessmaskingformulation optimization. J. Pharm Sci. 16(10): 2723-34 (2007). LLi, V Naini, S UAhmed S  Taste masking analysis in pharmaceutical formulation development using an electronic tongue. Int Pharm J. 310(1-2): 118-124 (2006). JY Zheng and MP Keeney S Quininesulphatepelletsforflexiblepediatricdrugdosing:Formulationdevelopment andevaluation of taste-masking efficiency using the electronic tongue. Eur. J. Pharm. Biopharm. 66(3): 460-465 (2007). PC Kayumba and JP Remon S EvaluationofanElectronicTasteSensorforuseinformulationdevelopment.AAPSannualmeeting presentation (2005) - publication in process. J Lorenz and J Reo S Evaluation of the taste and smell of bottled nutritive drinks. Int Pharm J. 305(1-2):13-21 (2005). M Kataoka and T Uchida S Application of an electronic nose system for evaluation of unpleasant odor in coated tablets. Eur. J. Pharm. Biopharm. 59(2): 289-297 (2005). S Ohmori and T Kashihara S FlavoranalysisinapharmaceuticaloralsolutionformulationusinganelectronicnoseJ.PharmBiomed Anal. 34(3):453-61 (2004). LZhu and JC Mifsud EMEA FDA Eli Lilly Barr Pharmaceuticals Ghent University Pfizer Mukogawa Women’s University Takeda Merck OTC Generic Rx Scientific & regulator y references Impression SRI feuille - 05.34.27.46.62