ROXY - Electrochemistry / MS - Products & Parts Catalogue - Alpha MOS - #9

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Proven EC-Systems to guarantee your performance 9 EC Systems for MS ® ROXY ™ EC System Dedicated Electrochemistry system for EC/MS • Single compound conversion (oxidation/reduction) • D irect on-line EC/MS, without chromatography (LC) • A ll parts supplied for imm ediate installation and use • Fast metabolite profiling Phase 1 and 2 metabolism • H uge time and cost savings The ROXY™ EC is the ideal introduction system for Electrospray Ionization (ESI)-MS for single compound conversion. For known compounds (e.g., drug candidates, pollutants, pesticides, etc) a quick profiling and/or reconfirmation of potential metabolites is often sufficient for decision making. Therefore, target compounds can be directly infused through the electrochemical ReactorCell™ into the MS, often without the need of any liquid chromatographic separation (HPLC), making EC/MS a very powerful tool for fast metabolic profiling and related applications. The resulting time and cost savings are substantial when compared with daunting in vivo or in vitro experiments. The ROXY™ EC System is supplied with a dual syringe infusion pump and all connecting tubing and parts for immediate installation and use. MS Potentiostat Pump Phase I: oxidation reactions, e.g., oxidative metabolism, biotransformation reaction, etc. Phase II: adduct formation, e.g., conjugation of the oxidized / activated compound with GSH, HSA, drug-protein binding studies, etc. Structure and calotte model of Amiodarone (antiarrhythmic drug) containing two iodine atoms Schematics ROXY™ EC System for on-line Electrochemistry/MS