Zeta plus maximizer ext with SP media - 3M Purification Inc. - #1

Featuring Dual Zone SP Filter Media

■ Increased throughput with high turbidimetric efficiency

■ Enhanced protection of downstream membrane filters

■ A complete particle retention range from coarse to fine

■ Open grade EXT filters are designed for primary clarification or to replace centrifuges and TFF systems

■ Consolidation of multiple filter stages resulting in lower processing costs

The new Zeta Plus EXT Series filter extends depth filtration capacity and extends protection of downstream membranes thereby extending filter life and lowering overall filtration costs. Zeta Plus EXT Series is a family of advanced dual zone depth filters designed to provide optimal clarification of bioprocess, biological and pharmaceutical fluids. Zeta Plus EXT Series filters consist of two distinct layers, or "zones" offilter mediawiththe upstream zone more open than the down stream zone. This structure en­hances the contaminant holding capacity of the filter media, since larger particles are trapped in the upper zone of the filter media and smaller particles are trapped in the lower zone, reducing premature plugging and extending service life.

Applications

Applications

EXT filters with SP media are optimized for clarification ofmammalian cell harvest fluids, clarification ofhigh protein concentrationfeed streams and foroptimal protection ofdown-stream sterilizing grade membrane filters. Zeta Plus SP media is composed ofinorganic filter aid, cellulose and a proprietary resin system that imparts a positive charge to the filter matrix.

Superior Performance

Advances in mammalian cell line engineering, DNA transfer vector and cell culture media have increased protein yields in mammalian cell cultures by a factor of 10 over the last decade. This increase in part is due to the increased cell titers atharvest. Thus, the biopharmaceutical industry has encountered a new challenge to improve primary cell clarification while mini­mizing protein loss. Zeta Plus EXT Series filters with SP media are designed to fulfill this unmet need. Zeta Plus SP media is an advanced cellulose-based depth filtrationmedia, designed to retain contaminants by both mechanical entrapment and electrokinetic adsorption. Zeta Plus fil­ter media is composed of high surface area filter aids embedded in a cellulose fiber matrix. During the manufacturing process, molecules carrying a positive charge are chemically bonded to the filter matrix permanently forming an interconnected filtration structure with positively charged electrokinetic capture sites. The resulting porous depth filter is a tortuous network of charge en­hanced flow channels capable ofremoving bacteria, particulate, cellular debris and submicronic contaminants.